Lake Nipigon
Prolific trophy brook trout make pristine Lake Nipigon a prime destination throughout the open-water season. The endless shoals and hidden reefs in Ontario’s largest inland lake also provide good walleye and pike fishing. Nearby Colimar Lodge boasts excellent accommodations and fishing charters. 1-877-275-9198; www.colimarlodge.ca

Cree River
Saskatchewan’s Cree River is packed with large, hungry Arctic grayling anxious to devour Elk Hair Caddis, Parachute Adams and Irresistible flies. Just a short boat trip from Cree Lake Lodge, the river also holds jumbo whitefish and, in deeper holes, big northern pike. (306) 344-4862; www.creelakelodge.com

Eagle River
Renowned for its hard-fighting Atlantic salmon, Labrador’s mighty Eagle River is a world-class fly-fishing destination. From late June to early September, there’s fantastic angling for salmon up to 20 pounds and bigger. Eagle’s Spirit Wind Salmon Lodge offers a variety of angling packages. 1-877-896-8142; www.eagleriveroutfitters.ca